Empowering you to be your best diagnostician
Get a differential diagnosis with the diseases you are expecting AND unfamiliar diseases that should be considered for your patient.
Suggestions of useful findings and tests
Get prompted with useful findings and tests, driven by the evolving differential diagnosis. Diagnosis is iterative, far better than a one-shot Web search. Even comment on pertinent negative findings. Or click the magnifying glass in the software to use our new improved search.
Use genomic data, even crunch data from commercial labs
Get the full clinical correlation offered by the Genome-Phenome analyzer by importing genomic variant tables to identify the genes most pertinent to your patient's findings. Use input from your own lab, or use variant tables from commercial labs: just identify the key columns needed for the analysis. You can even get help with gene discovery and incidental ("secondary") genes.
Mobile device support
Now runs on mobile devices as well as computers, so you can use it whenever you need it. There is no app to install. Just navigate to the software as you would on a personal computer.
Loss of heterozygosity
Use your microarray results to consider genes in regions of loss of heterozygosity. Then get suggestions of other useful clinical findings or tests to make the diagnosis or guide testing.
Sophisticated time model
Use onset and disappearance age of findings, and speed of emergence of your patient's disease to distinguish among diseases with similar findings but different time course.
Prognosis table
Offer your patient and referring physicians a highly-rated table of what to expect over time for each disease you diagnose.
Sophisticated family history model
Combines a simple interface for family history with a very sophisticated model under the hood. As an example, X-linked diseases are considered as a spectrum between dominant and recessive, specified for each disease in the database but displayed in a way that is simple for the user.
Beyond the trio genomic analysis
If you have more genomic data than just a trio, such as siblings, cousins, or even unrelated individuals, the Genome-Phenome Analyzer can use the information and narrow down the analysis, even for gene discovery.
Lots of links to articles and pictures
When a disease or finding is active, explore the Tips links for explanations, calculators, articles and photos. Read our roundup of different types of skin lines to brush up on dermatomal vs. Blaschko versus Langer lines of cleavage. Or get a head circumference percentile.
ABOUT US
Designed by doctors for doctors
Designed by doctors for doctors. We know you rarely need help with diagnosis in your specialty, but with the extraordinary growth of medical knowledge, you may value prompts about unfamiliar candidate diseases in adjacent specialties. That is why we have built SimulConsult as a single model across all specialties, so that the differential diagnosis includes both the diseases you are expecting and also unfamiliar diseases that should be considered for your patient.
Differential diagnosis
An 8-month old boy presented at an emergency department with severe macrocephaly, progressing rapidly. The pediatrician was worried about a brain tumor, but a careful exam revealed the finding of kyphosis, which the mother knew had onset at 6 months of age. With just the finding of kyphosis, one gets a differential diagnosis, with blue shading to indicate the probability of each candidate disease. Click the arrow at right to see the next step.
Useful findings
Among the suggested findings is short stature, because some of the diseases in the differential diagnosis include short stature. The boy was not short. In achondroplasia, the #1 disease, patients would already be short. Adding this pertinent negative makes achondroplasia go away. Similarly, macrocephaly appears next, and adding it puts MPS I (Hurler syndrome) as #1 as shown here (Onsets are crucial - kids with MPS I are all short, but not by 8 months). Corneal clouding is now the most useful finding, and when it is specified, the diagnosis of Hurler syndrome will become far more likely than shown here without it.
Assess disease
Having made a preliminary diagnosis of MPS I, you are ready to assess the diagnosis. Highlighting MPS I and clicking Assess, you experience the "Explainable AI": comparing your patient’s pertinent positives and negatives to what is known for the disease, considering both frequency and onset. Examining such screens is a perfect display as you are dictating your note.
