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Chat interfaces

Two new chat-based interfaces encourage a team approach to diagnosis that includes both patients and primary care clinicians.

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Explainable AI

The software differs from large language models in being able to explain its reasoning. The interface is changed to reflect that, and to make it easier to compare explanations for the various diseases in the differential diagnosis.

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Computable Patient Summaries are now clickable URLs

The computable patient summary is now a URL that can be clicked to re-load the patient. This allows you to share the URL with colleagues, for example by email or pasting into a chart note.

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Risk Warnings

The software now uses red asterisks near the names of diseases to indicate situations in which there is a non-obvious risk that can be avoided.

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Natural Language Processing

You can now enter findings using Natural Language Processing.

Medical Articles

Vanderbilt finds significant time savings by using the SimulConsult diagnostic software

Hash and colleagues at Vanderbilt University Medical Center found that the SimulConsult diagnostic software saved time and was perceived by clinicians as useful in improving diagnosis.

Medical Articles

Study shows efficacy of a Genome-Phenome Archiving and Communication System with SimulConsult

Kulchak Rahm and colleagues combined Natural Language Processing of Electronic Health Record (EHR) data with SimulConsult’s ability to discern what information is useful. The result was a system that identifies useful information in the EHR, and uses it for accurate diagnosis.

Company News

Follow Your Nose to Herd Immunity

The Centers for Disease Control and Prevention’s latest Covid guidelines have many Americans confused. Vaccinated people are supposed to resume wearing masks, lest they contract and spread the virus. Yet unvaccinated people are still strongly urged to get the shots, which are said to be highly effective. How can both these claims be true?

Medical Articles

Vanderbilt geneticists cite importance of using SimulConsult for genetic diagnosis

In a research paper, geneticists at Vanderbilt University Medical Center discussed their protocol for using SimulConsult in the diagnosis process. They suggested “In addition to increased communication, programs such as OMIM and SimulConsult can be used to analyze combinations of signs and symptoms to identify and prioritize differential diagnoses.”

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SimulConsult software running on a Peloton

The SimulConsult software runs just about everywhere, so we checked whether it could run on a Peloton exercise bicycle. Using the guidance (see hyperlink) for how to find the web browser on the Peloton, we found that indeed the software runs fine.

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SimulConsult software even runs on the new iPhone 12 mini

The SimulConsult software is most conveniently run on a regular computer or a tablet such as an iPad mini. But with the release of the iPhone 12 mini that fits in your pocket conveniently, we’ve made sure the software even runs with that small screen size so you use it whenever you need it. Even the genome analysis fits on the screen, but that is not something anyone will expect you to do on the go.

Medical Articles

SimulConsult supports both old and new HGNC gene symbols

The SimulConsult Genome-Phenome Analyzer supports all HGNC gene symbols in use since 1 January 2010, even if the symbol has been changed. The hyperlinked article details how HGNC is systematically changing all the symbols that Excel turns into dates in a spreadsheet. But even if you use the old symbols such as SEPT12 in a variant table, or search for it in the software, SimulConsult recognizes that as being the HGNC symbol SEPTIN12.

Medical Articles

Efficacy study of the Genome-Phenome Analyzer published in Orphanet Journal of Rare Diseases

In the 81 cases (with 216 individuals) the gene abnormality was recognized in 100%, and it was ranked #1 in 94% of cases. Large CNVs could be analyzed in an integrated analysis, performed in 24 of the cases. The process is rapid enough to allow for periodic reanalysis of unsolved cases.

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UCSD study shows high efficacy for SimulConsult Genome-Phenome Analyzer

“In all families (84 pregnancies) pertinence was > 95% between signs/symptoms and molecular cause”, meaning that not only was the correct diagnosis ranked as #1 but no other diagnoses were close.

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The Complicated Truth About Vaccines

Published in the Wall Street Journal on May 1, 2019 by Michael Segal, MD PhD

They can appear to be the proximate cause of a condition when they have nothing to do with the ultimate cause. Why are people afraid of vaccines?

See letter in response on 13 May.

Company News

SimulConsult releases new mobile version of its Phenome Analyzer and Genome-Phenome analyzer software

Released April 1, 2019

SimulConsult announces a new version of its diagnostic decision support tool. The tool combines the power of
curated human expertise and computational artificial intelligence (AI) to empower clinicians in diagnosis and
workup of patients. It is used today in 118 countries. The new version has a completely new interface that allows it to run on mobile devices as well as on computers. It is fast to use and puts the diagnostic power into a clinician’s hands whenever needed.

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A Genotype-Phenotype Archiving and Communication System

SimulConsult’s newly-formed research partner, PhenoSolve, LLC., received an SBIR I from the National Human Genome Research Institute (NHGRI) of the NIH beginning September 19, 2018 with Michael M. Segal MD PhD as Primary Investigator

The rationale is that the current state of genome analysis and clinical use is lagging in part due to a situation of siloed information and capabilities, a situation that Clayton Christensen characterizes as requiring end-to-end integration to set the stage for a subsequent environment of interoperable standards. While analogous to the radiology PACS, the G-PACS will also have advanced analysis capabilities and sophisticated handling of 2 types of information – patient findings and annotated genomic variants to enable genome-phenome analysis by clinicians and laboratorians using these components.

Medical Articles

Experience with Integrating Diagnostic Decision Support Software with Electronic Health Records: Benefits versus Risks of Information Sharing

Published in The Journal for Electronic Health Data and Methods on December 6, 2017 by Michael M. Segal, Alanna K. Rahm, Nathan C. Hulse, Grant Wood, Janet L. Williams, Lynn Feldman, Gregory J. Moore, David Gehrum, Michelle Yefko, Steven Mayernick, Roger Gildersleeve, Margie C. Sunderland, Steven B. Bleyl, Peter Haug, Marc S. Williams

The article describes the result of an NIH-sponsored study of integrating SimulConsult’s diagnostic decision support system with Electronic Health Record systems.

Medical Articles

Impact of a Patient-Facing Enhanced Genomic Results Report to Improve Understanding, Engagement, and Communication

Published in the Journal of Genetic Counselors in April 2018 (open access) by Williams JL, Rahm AK, Zallen DT, Stuckey H, Fultz K, Fan AL, Bonhag M, Feldman L, Segal MM, Williams MS.

The article describes the result of a PCORI-sponsored study of providing information about genetic testing to patients, including a display driven by the highly granular onset information in SimulConsult’s diagnostic decision support system.

Company News

Testing Pediatric Rheumatology Diagnostic Decision Support in Clinical Use

SimulConsult receives SBIR II from the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the NIH of the NIH beginning August 1, 2017 with Michael M. Segal MD PhD as Primary Investigator

This research aims to ease the shortage of pediatric rheumatologists by using decision support software to improve the ability of generalist physicians to make rheumatologic diagnoses. It extends to actual clinical practice our previous work that demonstrated large reductions in diagnostic error when tested using written case summaries, using a randomized controlled study. The research will be done after implementing improvements to the diagnostic tool suggested by the earlier pilot study.